The Heart Attack Grill is an American hamburger restaurant in downtown Las Vegas, Nevada (formerly located in Chandler, Arizona). It makes a point of serving food that is high in fat, sugar and cholesterol; in other words, food that, if eaten regularly, would cause a heart attack, hence the name.

The establishment is a hospital theme restaurant: waitresses ("nurses") take orders ("prescriptions") from the customers ("patients"). Each patient dons a hospital gown and wrist band before ordering and those who do not finish their meal receive a paddling by one of the "nurses" with the option to buy the paddle afterwards.

The menu is generally themed around items that are exceptionally high in calories and fat. It includes "Single", "Double", "Triple", "Quadruple", all the way up to "Octuple Bypass" hamburgers, ranging from 8 to 32 ounces (230 to 910 g) of beef (up to about 8,000 calories (33,000 kJ)), all-you-can-eat "Flatliner Fries" (cooked in pure lard), beer and tequila, "butterfat milkshakes," and soft drinks such as Mexican-bottled Coca-Cola made with cane sugar. Customers can also order cigarettes, or candy cigarettes for children.

Customers over 350 lb (160 kg) in weight eat for free if they weigh in with a nurse waitress before eating. Beverages and to-go orders are excluded and sharing food is also not allowed for the free food deal.

One of the restaurant's promotions is a reward for customers who finish a Triple or Quadruple Bypass Burger, after which they are placed on a wheelchair and wheeled out to their vehicle by their "personal nurse".